Urea alkanoic acid

A stimulating development of urea alcoholysis has been demonstrated very recently for better AE, in an innovative integrated process that incorporates fatty ester hydrolysis to co-amino-alkanoic acids [44], Within the scope of this chapter, the most interesting step of this process is the recycling of waste alcohol, formed by the hydrolysis step, for urea alcoholysis. Dialkyl carbonate is produced together with ammonia thereafter, the ammonia is engaged in the amination reaction to obtain the amino acids. The overall process avoids the storage of NH3 that is necessary for the amination route, and transforms a waste product-the alcohol-into the valuable dialkyl carbonate. 

Several recent patents42 127 128 describe the preparation of 4,5-disubsti-tuted oxazole-2-yl alkanoic acids (58) by the reaction of an a-ketol ester with urea in acetic acid or by acetylation of an a-ketol with a cyclic anhydride followed by refluxing with ammonium acetate in acetic acid. 

To the first class belong systems such as alkanoic acids, methylnicotinate, salicylic acid and urea extracted by liquid hydrocarbons or big esters such as isopropyl-tetradecanate (isopropyl-myristate (IPM)). 

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