Upstream colocated PAT sampler

This configuration has still another potential bonus. For the upstream sampler, especially in the loop configuration, it is not advantageous to employ large-diameter piping. Indeed it is optimal to specifically use a narrow diameter. 

For moving streams of particnlate matter (aggregate matter, slnrries), typically transported nsing conveyor belts or similar horizontal agents (slides, tmcks, railroad cars, etc.), the eqnivalent principal solntion is the cross-stream cutter, as is illustrated in Fignre 3.22. 

This case is well described, depicted and illustrated in the pertinent TOS literatnre, especially with reference to the mining, cement and other process industries [1-3,9-14,21] and need therefore not be dealt with farther here. Below the focus is on pipeline and reactor scenarios, specifically for liqnid solutions and mix-tmes, slurries, powders and similar materials of more direct interest to the pharmaceutical and chemical and related industries (food, feed, other). 

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