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Uncoupling protein 2 UCP

Figure 18.45. Action of an Uncoupling Protein. Uncoupling protein-1 (UCP-1) generates heat by permitting the influx of protons into the mitochondria without the synthesis of ATP. Figure 18.45. Action of an Uncoupling Protein. Uncoupling protein-1 (UCP-1) generates heat by permitting the influx of protons into the mitochondria without the synthesis of ATP.
Uncoupling results in dissipation of the respiratory chain-produced ApH+ due to increased conductance of the inner mitochondrial membrane. Thus energy released by respiration is immediately dissipated as heat without formation and hydrolysis of ATP. Non-esterified fatty acids proved to be compounds mediating the thermoregulatory uncoupling. They operate as protonophorous uncouplers with the help of special uncoupling proteins (UCPs) or some mitochondrial antiporters i.e. the ATP/ADP antiporter and aspartate/glutamate antiporter [1-5]. [Pg.3]

Fumeron F, Durack-Bown 1, Betoulle D, et al. Polymorphisms of uncoupling protein (UCP) and beta 3 adrenoreceptor genes in obese people submitted to a low calorie diet. Int. J. Obes. Relat. Metab. Disord. 1996 20 1051—1054. [Pg.112]

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