Ultrasmall superparamagnetic iron oxide

Muller, K., Skepper, J.N., Posfai, M., Trivedi, R., Howarth, S., Corot, C., Lancelot, E., Thompson, P.W., Brown, A.P., and Gillard, J.H. (2007) Effect of ultrasmall superparamagnetic iron oxide nanoparticles (Ferumoxtran-10) on human monocyte-macrophages invitro. Biomaterials, 28 (9), 1629-1642. 

U)SPIO (ultrasmall) superparamagnetic iron oxide (h)TfR (human) transferrin receptor... 

Tang T, Howarth SP, Miller SR et al. (2006). Assessment of inflammatory burden contralateral to the symptomatic carotid stenosis using high-resolution ultrasmall, superparamagnetic iron oxide-enhanced MRI. Stroke 37 2266-2270... 

Sharma R, Saini S, Ros PR, Hahn PF, Small WC, de Lange EE, Stillman AE, Edelman RR, Runge VM, Outwater EK, Morris M, Lucas M. Safety profile of ultrasmall superparamagnetic iron oxide ferumoxtran-10 phase II clinical trial data. J Magn Reson Imaging 1999 9(2) 291-4. 

R. Weissleder, G. Elizondo, J. Wittenberg, C. A. Rabito, H. H. Bengele, and L. Josephson, Ultrasmall superparamagnetic iron-oxide—characterization of a new class of contrast agents for MR imaging. Radiology, 175 (1990) 489-493. 

Di Marco, M. Sadun, C. Port, M. Guilbert, I. Couvreur, P. Dubemet, C., Physicochemical characterization of ultrasmall superparamagnetic iron oxide particles (USPIO) for biomedical application as MRI contrast agents. International Journal of Nanomedicine 2007, 2, (4), 609-622. 

Superparamagnetic Iron Oxide Particles and Ultrasmall Superparamagnetic Iron Oxide Nanoparticles 533... 

Weissleder R, Elizondo G, Wittenberg J, Lee AS, Josephson L, Brady TJ (1990) Ultrasmall superparamagnetic iron oxide an intravenous contrast agent for assessing lymph nodes with MR imaging. Radiology 175 494-498... 

Table 4 Some superparamagnetic and ultrasmall superparamagnetic iron oxide agents for use as contrast media in magnetic resonance imaging...

Hamm B, De Kerviler E, Gaillard S, Bonnemain B. Safety and tolerability of ultrasmall superparamagnetic iron oxide contrast agent. Comprehensive analysis of a clinical development program. Invest Radiol 2009 44 336-42. 

Beilin MF, Roy C, Kinkel K et al. (1998) Lymph node metasta-ses safety and effectiveness of MR imaging with ultrasmall superparamagnetic iron oxide particles—initial clinical... 

Magnetic resonance imaging (MRI) is at the forefront of non-invasive medical imaging techniques. Ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles are attractive MRI contrast agents due to their negative T2) contrast enhancement capability and biocompatibility. 

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