Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

UDP-GlcNAc 2-epimerase/ManNAc

GNE UDP-GlcNAc 2-epimerase/ManNAc 6-kinase GDP guanidine diphosphate hEBD human embryoid body-derived... [Pg.2135]

Penner J, Mantey LR, Elgavish S et al. (2006) Influence of UDP-GlcNAc 2-Epimerase/ManNAc kinase mutant proteins on hereditary inclusion body myopathy. Biochemistry AS, 2968-2977. [Pg.188]

Kurochkina N, Yardeni T, Huizing M. (2010) Molecular modeling of the bifunctional enzyme UDP-GlcNAc 2-epimerase/ManNAc kinase and predictions of structural effeds of mutations assodated with HIBM and sialuria. Glycobiology 20, 322-337. [Pg.188]

Wang Z, Sun Z, Li AV, Yarema KJ. (2006) Roles for UDP-GlcNAc 2-epimerase/ManNAc 6-kinase outside of sialic add biosynthesis modulation of sialyltrans-ferase and BiP expression, GM3 and GD 3 biosynthesis, proliferation, and apoptosis, and ERKl/2 phosphorylation. JEM Chem 281(37), 27016-27028. [Pg.205]

Figure 10 The sialoside biosynthetic pathway in eukaryotic cells A, UDP-GlcNAc-2-epimerase B, ManNAc-6-kinase C, Neu5Ac-9-P04 synthase D, NeuSAc-b-POj phosphatase E, CMP-Neu5Ac-synthetase F, sialyltransferase. Enzymes A and B function together as a bifunctional enzyme. Figure 10 The sialoside biosynthetic pathway in eukaryotic cells A, UDP-GlcNAc-2-epimerase B, ManNAc-6-kinase C, Neu5Ac-9-P04 synthase D, NeuSAc-b-POj phosphatase E, CMP-Neu5Ac-synthetase F, sialyltransferase. Enzymes A and B function together as a bifunctional enzyme.
Figure 11.1 The sialic acid biosynthetic pathway. Sialic acid biosynthesis occurs within the cytosol and is governed by the bifunctional enzyme GNB, which has two domains that possess enzymatic activities UDP-GlcNAc 2-epimerase and ManNAc kinase. Synthesis starts with the epimerization of UDP-GlcNAc to ManNAc by UDP-GlcNAc 2-epimerase after the release of UDP in a two-stage process. Phosphorylation of ManNAc is catalyzed by ManNAc kinase, but in some hyposialylated cells this canbe done by GlcNAc kinase. Subsequent steps lead to formation of free... Figure 11.1 The sialic acid biosynthetic pathway. Sialic acid biosynthesis occurs within the cytosol and is governed by the bifunctional enzyme GNB, which has two domains that possess enzymatic activities UDP-GlcNAc 2-epimerase and ManNAc kinase. Synthesis starts with the epimerization of UDP-GlcNAc to ManNAc by UDP-GlcNAc 2-epimerase after the release of UDP in a two-stage process. Phosphorylation of ManNAc is catalyzed by ManNAc kinase, but in some hyposialylated cells this canbe done by GlcNAc kinase. Subsequent steps lead to formation of free...
UDP-GlcNAc 2 epimerase UDP-GlcNAc ManNAc + UDP CMP-Neu5Ac cytosol... [Pg.245]

This topic may be physiologically very important, but it is not well understood. A human genetic disorder called sialuria shows the importance of at least one prediction from in vitro studies. In this condition, large amounts of sialic acid (5-7 g/day) are secreted into the urine along with various intermediates in the UDP-GlcNAc--->CMP-Sia pathway [86, 87]. This was confirmed to be due to a defective feed-back inhibition of the 2-epimerase/ManNAc kinase, the first step in the pathway [88]. [Pg.1136]

In mammals the epimerase (Eq. 20-7, step a) probably utilizes a similar chemical mechanism but eliminates UDP and replaces it with HO" to give free N-acetylmannosamine, which is then phosphor-ylated on the 6-hydroxyl (Eq. 20-7, step b). ManNAc may also be formed from free GlcNAc by another 2-epimerase (step a").47C/d... [Pg.1136]

N-acetylmannosamine kinase N-acyl-D-mannosamine kinase UDP-GlcNAc-epimerase/ManNAc kinase <2-4> [8-13] acetylamidodeoxymannokinase acetylmannosamine kinase acylaminodeoxymannokinase acylmannosamine kinase acylmannosamine kinase (phosphorylating)... [Pg.144]

Experiments with an 0-labelled sugar indicated that the UDP-JV-acetylgluco-samine 2-epimerase-catalysed equilibration of UDP-GlcNAc with UDP-ManNAc proceeds via 2- acetamido-D-glucal. ... [Pg.110]

See other pages where UDP-GlcNAc 2-epimerase/ManNAc is mentioned: [Pg.2152]    [Pg.1047]    [Pg.2152]    [Pg.1047]    [Pg.335]    [Pg.200]    [Pg.145]    [Pg.9]    [Pg.255]    [Pg.179]    [Pg.180]    [Pg.199]    [Pg.202]    [Pg.244]    [Pg.246]    [Pg.247]    [Pg.2134]    [Pg.2135]    [Pg.2135]    [Pg.202]    [Pg.179]    [Pg.452]   


SEARCH



Epimerases

GlcNAc

GlcNAc 2-epimerase

ManNAc

UDP

UDP-GlcNAc

© 2024 chempedia.info