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UDP-GlcNAc

A second GIcNAc residue is added to the first, again using UDP-GlcNAc as the donor. [Pg.522]

An important additional pathway is indicated in reactions I and II of Figure 47-9. This involves enzymes destined for lysosomes. Such enzymes are targeted to the lysosomes by a specific chemical marker. In reaction I, a residue of GIcNAc-1-P is added to carbon 6 of one or more specific Man residues of these enzymes. The reaction is catalyzed by a GIcNAc phosphotransferase, which uses UDP-GlcNAc as the donor and generates UMP as the other product ... [Pg.524]

UDP-GlcNAC enolpyruvyltransferase (MurZ) catalyzes the reaction between the phosphate of the enol pyruvate and the UDP-GlcNAC to form the corresponding enolpyruvate. This reaction is the first stage of the biosynthesis of the peptidoglycan of the bacterial wall. Phosphates of mono- and difluoroenolpyruvates are substrates of MurZ (Figure 7.30). The tetrahedral intermediates formed after incubation... [Pg.244]

This assumption comes from the high amount of Neu2en5Ac found in serum and urine of this patient the compound is considered to be derived from CMP-Neu5Ac in a nonenzymic, elimination reaction found to occur under physiological conditions (see later)170 238 239. Thus, lack of acylneuraminate cytidylyltransferase (EC 2.7.7.43) activity as the reason for a diminution of the concentration of CMP-Neu5Ac and, therefore, lessened feedback-inhibition of UDP-GlcNAc 2-epi-merase, can largely be excluded. [Pg.180]

That some cell-free systems were incomplete became evident when the role of UDP-Glc was appreciated (see Refs. 127-135). Only in the presence of UDP-Glc (in addition to UDP-GlcNAc and GDP-Man, when no endogenous acceptors are present) was a lipid-linked oligosaccharide obtained that had the same chemical properties as the D-... [Pg.307]

Undecaprenol-P + UDP-GlcNAc —> GlcNAc-P-undecaprenol + UDP (13) GlcNAc-PP-Dol + UDP-GlcNAc -> (GlcNAc)2-PP-Dol + UDP (8)... [Pg.341]

Keller and coworkers341 proposed that tunicamyein is a reversible, tight-binding, and, therefore, competitive inhibitor of the GlcNAc 1-P transferase. The association rate-constant was 7 x 104 M s 1 (at 23°). Inhibition can be overcome by increasing the proportion of enzyme, and, because preincubation of the enzyme with UDP-GlcNAc prevented inhibition by tunicamyein,341 some experimental support for competitive inhibition was obtained. The known affinity of the antibiotic for phosphonolipids323 may facilitate its access to the membrane-bound enzyme, but the lipids do not prevent inhibition of the enzyme by tunicamyein.340... [Pg.342]


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See also in sourсe #XX -- [ Pg.100 , Pg.130 , Pg.138 ]

See also in sourсe #XX -- [ Pg.24 ]

See also in sourсe #XX -- [ Pg.2157 , Pg.2168 ]

See also in sourсe #XX -- [ Pg.537 , Pg.543 ]

See also in sourсe #XX -- [ Pg.417 ]




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Enzyme UDP-GlcNAc)

GlcNAc

UDP

UDP-GlcNAc 2-epimerase/ManNAc

Uridine diphosphate-N-acetylglucosamine UDP-GlcNAc)

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