Ubiquitin Skpl-Skp2 complex

ScHULMAN, B. A., et al., Insights into SCF ubiquitin ligases from the structure of the Skpl-Skp2 complex. 

Elucidation of the structure of the SCF ubiquitin E3 ligase complex and their substrates should help resolve certain issues regarding the mechanism by which SCF E3 ligase promotes ubiquitin transfer from the E2 enzyme to the protein substrate. Recently, the structures of Cull/Rocl in complex with Skpl and Skp2, as well as that of Skpl/jS-Trcp and Cdc4, have been reported [21, 25, 55, 56]. These studies... 

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