Two-Dimensional Sequences Developed from Solution NMR

Two dimensional sequences are commonly used in solution state NMR spectroscopy to elucidate connectivity of atoms within molecular structures. Sequences are available for heteronuclear shift correlation, homonuclear correlation (COSY and INADEQUATE) and other sequences for longer-range connectivities. In general the basis of these 

The presence of anisotropic interactions in solids leads to a greater variety of 2D sequences. One of the simplest is the isotropic/anisotropic correlation, where high resolution is achieved in one dimension while preserving anisotropic information in the second dimension. The dipshift and J-resolved experiments correlate isotropic chemical shift with dipolar and J-coupling information respectively. In these sequences the 

These are just some examples of the burgeoning field of 2D applications to solids. Other references are given in Table 3.4. In order to provide an even greater spread of information, three-dimensional sequences have now been developed which are essentially combinations of 2D sequences. Their rapid development has arisen through 

COSY Homonuclear connectivity Fyfe etal. (1989), Kohn etal. 99 ), Hanna et al. (1992) 

INADEQUATE Homo/heteronuclear connectivity when coupling is weak Benn et al. (1988) 

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