Two-dimensional molecular recognition

Synthesis and Characterization of Two-Dimensional Molecular Recognition Interfaces... 

CROOKS ETAL. Two-Dimensional Molecular Recognition ItUeifoces 115... 

Y. Oishi, Y. Torii, M. Kuramori, K. Suehiro, K. Ariga, K. Taguchi, A. Kamino, T. Kunitake, Two-Dimensional Molecular Patterning through Molecular Recognition , Chem. Lett, 6,411 (1996)... 

Finally, to produce the structural and functional devices of the cell, polypeptides are synthesized by ribosomal translation of the mRNA. The supramolecular complex of the E. coli ribosome consists of 52 protein and three RNA molecules. The power of programmed molecular recognition is impressively demonstrated by the fact that aU of the individual 55 ribosomal building blocks spontaneously assemble to form the functional supramolecular complex by means of noncovalent interactions. The ribosome contains two subunits, the 308 subunit, with a molecular weight of about 930 kDa, and the 1590-kDa 50S subunit, forming particles of about 25-nm diameter. The resolution of the well-defined three-dimensional structure of the ribosome and the exact topographical constitution of its components are still under active investigation. Nevertheless, the localization of the multiple enzymatic domains, e.g., the peptidyl transferase, are well known, and thus the fundamental functions of the entire supramolecular machine is understood [24]. 

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