Twitchin kinase

Structural information on autoinhibition is available for the twitchin kinase. The twitchin kinase is a Ser/Thr-specific protein kinase of the nematode Caenorhabditis ele-gans and is homologous to the myosin light chain kinase of mammals (see 7.4.1). The crystal structure of a catalytic fragment of twitchin kinase (Hu et al., 1994) has an auto-inhibitory element at the C-terminus, which makes specific contact with parts of the active site and the ATP binding site. The active site of twitchin kinase is blocked by the autoinhibitory structural element by ... 

It is documented for the crystal structures of inactive human CDK2 and the partially activated human CDK2-cyclin A complex that large conformational changes of the activation segment occur [48], Comparing the position of the activation segment in the structures for Twitchin Kinase, IRK, calmodulin-depend kinase I (CaMKI), and MAPK, a variety of conformations are revealed that are accessible to different kinases in their inactive state [15, 16, 49,... 

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