Tunicamycins total synthesis

Epimeric product 8 %) Scheme 5. Total synthesis of tunicamycin V... 

Tunicamycin V (formerly "A") (26) has been prepared, together with 3 minor components of the complex and other analogues in the key step, the glycosyl chloride (27) was condensed with the reducing amino-sugar derivative (28), which was then conventionally converted to (26). Another communication reports a total synthesis of polyoxin J (29), converting 4-0-benzyl-2,3-0-isopropy-lidene-L-threose to deoxypolyoxin C (30) on the one hand and to the 5-0-carbamoyl-polyoxamic acid derivative (31) on the other, these... 

Full details of the "total" synthesis of tunicamycin V have been... 

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