Tumors Up to Three Centimeters in Size

The first clinical trial of electrochemotherapy was published in 1993 [29], with treatment of cutaneous metastases from head and neck cancer. This was followed by several studies of pahents with malignant melanoma metastases and basal cell carcinoma [30, 31]. In the first study, intravenous or intraarterial bleomycin was used, and in the latter intratumoral injechon of 5 U ml was used, for both the tumor and the surrounding area. In the first study, plate electrodes were used, where as in the latter a needle electrode device was used. 

In 2006, Mir et al. [15] described standard operating procedures for electroche-motherapy of tumors up to 3 cm, and these are now frequenhy referred to as a standard of care. Several studies, most of them based on the 2006 standard operating procedures, have now been published, and confirm both the level of response rates and toxicity profile. 

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