Tumors, energy metabolism

This is in contrast to the stimulation of the energy metabolism, following Rn/Rn-d exposure of lung tumor center, indicating possible tumor growth promotion by Rn/Rn-d exposure. 

Jones, G. R., Ellis, R., and Frohn, M. J. (1981) Drug-induced interference with energy metabolism in the SI80 sarcoma a new principle in the production of selective tumor injury. Oncodev. Biol. Med. 2,155-164. 

Okunieff, P., Kallinowski, F., Vaupel, P., and Neuringer, L. J. (1988) Effects of hydralazine-induced vasodilation on the energy metabolism of murine tumors studied by in vivo 31P-nuclear magnetic resonance spectroscopy. J. Natl. Cancer. Inst. 80, 745-750. 

Mirex replacements should not manifest the properties that led to the discontinuance of mirex for all uses namely, delayed mortality in aquatic and terrestrial fauna numerous birth defects tumor formation histopathology adverse effects on reproduction, early growth, and development high biomagnification and persistence dis-mpted energy metabolism degradation into... 

The nucleotide patterns of cultured animal cells and ascites tumor cells are generally less vulnerable than those of tissues however, if washing is required, a medium capable of supporting energy metabolism should be employed. If cells are to be packed by centrifugation prior to extraction, cultures or ascitic fluids may first have to be cooled. Cells are extracted in the cold some procedures employ alternate freezing and thawing in the presence of acidic extractants. Extraction of cultured mouse embryo cells with 60% methanol for 16 hours at — 20 C has been employed in the analysis of deoxyribonucleoside triphosphates 9). 

In vivo P-NMR spectroscopy has been employed in monitoring the energy metabolism of human tumors since 1983 (Griffiths etal. 1983). From the studies available, information is provided that may be beneficial in the clinical treatment of cancer. Furthermore, there are indications that serial monitoring of tumor response can assist in optimizing the timing of treatments. 

Bustamante E, Morris HP, Pedersen PL. Energy metabolism of tumor cells. Requirement for a form of hexokinase with a propensity for mitochondrial binding. J Biol Chem 1981 256 8699-8704. 

Haridas, V, Li, X., Mizumachi, T., Higuchi, M., Lemeshko, V. V., Colombini, M., and Gutterman, J.U. (2007) Avicins, a novel plant-derived metabolite lowers energy metabolism in tumor cells by targeting the outer mitochondrial membrane. Mitochondrion 7 234-240. 

Smith, T. C. Herlihy, J. T. Robinson, S. C. The effect of the fluorescent probe, 3,3 -dipropylthiadicarbocyanine iodide, on the energy metabolism of Ehrlich ascites tumor cells. J. Biol. Chem. 1981,256,1108-1110. 

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