Tumor angiogenesis regulation

Harper J, Moses MA (2006) Molecular regulation of tumor angiogenesis mechanisms and therapeutic implications. EXS 96 223-268... 

Cytokines such as interferons are used for the treatment of hepatitis, cancer, and lymphoma interleukins are used to enhance immune response and growth factors are used for the treatment of anemia and regulation of tumor angiogenesis. 

McCarty, M.F., Fish oil may impede tumor angiogenesis and invasiveness by down-regulating protein kinase C and modulating eicosanoid production, Med. Hypotheses, 46, 107, 1996. 

Increased tumor oxygenation actually reduces hypoxia-regulated VEGF levels and consequently tumor angiogenesis... 

Singh, R. K. and Fidler, I. J. (1996). Regulation of tumor angiogenesis by organ-specific cytokines. Curr. Top. Microbiol. Immunol. 213, 1-11. 

The receptor-like protein tyrosine phosphatases have a transmembrane and, in some cases, a large extracellular domain with a very variable structure (Fig. 8.19). Many, but not all, membrane protein tyrosine phosphatases have two catalytic domains in the cytoplasmic region. The overall structure is very similar to the structure of transmembrane receptors. Only recently, cellular ligands for receptor tyrosine phosphatases have been identified that function as their specific regulators. The receptor tyrosine phosphatase C has been found to be specifically inhibited by pleiotrophin, which is a cytokine implicated in tumor angiogenesis. Several studies have demonstrated a role for receptor PTPs in neuronal cell adhesion signaling pathways. In cells of the neural tissue, a surface protein, contactin, has been identified as an extracellular ligand of PTPa. 

Nie D, Krishnamoorthy S, Jin R, Tang K, Chen Y, Qiao Y, Zacharek A, Guo Y, Milanini J, Pages G, Honn KV. Mechanisms regulating tumor angiogenesis by 12-lipoxygenase in prostate cancer cells. J Biol Chem. 281 (2006) 18601-18609. 

W. Kolch, M.-G. Baron, A. Kieser, D. Marme (1995). Regulation of the expression of the VEGFA PS and its receptors role in tumor angiogenesis. Breast Cancer Res. Treat., 36, 139-155. 

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