Tumbling processes

Pelletization often does not require the use of excipients and may offer an alternative to blending for high dose therapeutics. The process involves deliberate agglomeration of the fine drug material into less cohesive, larger units [23]. Pelletization is usually achieved by vibratory sieving or any tumbling process. All processes require particu-... 

As already mentioned, we chose three different physicochemical properties for studying the influence of the surface area and fractal dimension in the ability of dendritic macromolecules to interact with neighboring solvent molecules. These properties are (a) the differential chromatographic retention of the diastereoisom-ers of 5 (G = 1) and 6 (G = 1), (b) the dependence on the nature of solvents of the equilibrium constant between the two diastereoisomers of 5 (G = 1), and (c) the tumbling process occurring in solution of the two isomers of 5 (G = 1), as observed by electron spin resonance (ESR) spectroscopy. The most relevant results and conclusions obtained with these three different studies are summarized as follows. 

Attention was then turned to encapsulation of a more reactive species, lithium aluminum hydride (Example 1). Several batches were encapsulated readily with poly (chloro-p-xylylene) utilizing the standard tumbling process. Products with from 1-20 wt. % coating were prepared. 

A more qualitative way of viewing the changes to the spectra in Figure 1.12, as a function of mj, is to consider the tumbling process as causing an averaging of... 

One of the simplest forms of direct addition is massage or rubs, a process that has been used on meat product for a great number of years and is actually the foreruimer of the tumbling process. 

Attrition and breakage refer to the phenomenon of granulation fragmentation in that are solidified by tray cooling to ambient temperature without the need for drying by a tumbling process. 

This process involves the agitating of suitably prepared parts to be coated with a mixture of nonmetallic impactors (e.g., glass beads), zinc powder, a chemical promoter, and water. All types of steel can be coated. However, this process is less suitable for parts heavier than V2 lb (250 g) because the tumbling process reduces coating thickness at the edges. 

One factor which affects the cost of both compression and transfer moulded parts is the fact that a certain amount of material may flash between the two parts of the mould while the molten material is under pressure. The amount of flash depends on the mould design but if it is appreciable it must be removed. In the case of small objects a simple tumbling process is usually sufficient but larger parts may have to be treated on a linisher or similar device. 

Figure 9.21 The tumbling process what would be observed by looking perpendicular to the plane of shear. (Reprinted from Marrucci, Pure Appl. Chem. 57 1545. Copyright 1985, with permission from the International Union of Pure and Applied Chemistry.)...

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