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Tubulin inhibitors therapy

DEVELOPMENT OF TUBULIN INHIBITORS AS ANTIMITOTIC AGENTS FOR CANCER THERAPY... [Pg.719]

The first compound of the taxanes series, paclitaxel (Taxol), was isolated from the bark of the Western yew tree in 1971. It and its congenic, the semisynthetic docetaxel (Taxotere), exhibit unique pharmacological actions as inhibitors of mitosis, differing from the vinca alkaloids and colchicine derivatives in that they bind to a different site on P-tubulin and promote rather than inhibit microtubule formation. The drugs have a central role in the therapy of ovarian, breast, lung, esophageal, bladder, and head and neck cancers. [Pg.537]

However, in 1942 it was removed from U. S. pharmacopeia because of its severe gastrointestinal toxicity. Currently, it still remains as an effective therapy for treatment of venereal warts [25]. Furthermore, podophyllotoxin and its derivatives have been extensively studied in the last 60 years for their powerful antitumor effects. Podophyllotoxin itself is a powerful microtubule inhibitor. Microtubules are tubular polymers whose protomeric unit (a and 3-tubulin) forms an heterodimer and are the dynamic constituents of the cytoskeleton. The cytoplasm of eukaryotic cells contains a soluble pool of unpolymerised tubulin protomers as well as an organised array of microtubules. Microtubules can be rapidly assembled or disassembled in response to various stimuli with little or no change in the total amount of tubuline. Cytoplasmatic microtubules are... [Pg.544]


See other pages where Tubulin inhibitors therapy is mentioned: [Pg.719]    [Pg.270]    [Pg.132]    [Pg.345]    [Pg.205]    [Pg.230]    [Pg.292]    [Pg.202]    [Pg.1]    [Pg.2]    [Pg.270]    [Pg.371]    [Pg.208]    [Pg.210]    [Pg.828]    [Pg.96]   
See also in sourсe #XX -- [ Pg.719 ]




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Tubulin inhibitors

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