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Trypanothione

Chibale K, Visser M, van Schalkwyk D, Smith PJ, Saravanamuthu A, Fairlamb AH (2003) Exploring the potential of xanthene derivatives as trypanothione reductase inhibitors and chloroquine potentiating agents. Tetrahedron 59 2289-2296... [Pg.184]

A third enzyme in the polyamine biosynthesis pathway, trypanothione synthetase-amidase (TRYS), has been shown to be essential by both genetic and chemical methods [24]. Specifically, the indazole analog 24 has been identified in a TRYS screen (IC50 = 140 nM) and shown to inhibit growth of wild-type (IC50 = 5.1 pM) and TRYS-dKO (IC50 = 0.46 mM) T. brucei parasites in culture [25]. [Pg.281]

Enzymes unique to the parasite and not found in humans (e.g., dihydropteroate synthesis enzymes, trypanothione reductase)... [Pg.585]

From Table 2 it is evident that only for three proteins, TIM, GAPDH, and trypanothione reductase the structures of the parasite and host enzymes are... [Pg.367]

Bradley, M., Bucheler, U. S. Walsh, C. T. (1991). Redox enzyme engineering conversion of human glutathione reductase into a trypanothione reductase. Biochemistry, 30,6124-7. [Pg.377]

Henderson, G. B., Murgolo, N.J., Kuriyan, J., Osapay, K., Kominos, D., Berry, A., Scrutton, N. S., Hinchlifife, N. W., Perham, R. N. Cerami, A. (1991). Engineering the substrate specificity of glutathione reductase toward that of trypanothione reduction. Proceedings of the National Academy of Sciences USA, 88, 8769-73. [Pg.380]

DNA circles in 219 mitochondria of 14 Trypanothione 552 Trypanothione reductase 785 Tryparsamide 597s... [Pg.936]

Trypanothione is a unique low molecular weight peptide containing spermid-... [Pg.341]

Reduction of trypanothione levels in the cells may be achieved in two ways (a) by inhibition of trypanothione peroxidase/reductase activity, or (b) by interference with the polyamine biosynthesis. Interference with the polyamine synthesis will not only lead to a decreased turnover of various polyamines, but will also bring down trypanothione levels in cells, thereby, exposing the parasites to the toxic effects of peroxides and free radicals generated by the host. [Pg.342]

See other pages where Trypanothione is mentioned: [Pg.178]    [Pg.280]    [Pg.429]    [Pg.610]    [Pg.357]    [Pg.359]    [Pg.552]    [Pg.785]    [Pg.262]    [Pg.42]    [Pg.423]    [Pg.424]    [Pg.424]    [Pg.1191]    [Pg.1195]    [Pg.1195]    [Pg.1203]    [Pg.39]    [Pg.59]    [Pg.9]    [Pg.748]    [Pg.112]    [Pg.178]    [Pg.286]    [Pg.718]    [Pg.718]    [Pg.552]    [Pg.785]    [Pg.101]    [Pg.199]    [Pg.200]    [Pg.341]    [Pg.342]    [Pg.342]    [Pg.748]    [Pg.96]   
See also in sourсe #XX -- [ Pg.552 ]

See also in sourсe #XX -- [ Pg.552 ]

See also in sourсe #XX -- [ Pg.552 ]

See also in sourсe #XX -- [ Pg.552 ]

See also in sourсe #XX -- [ Pg.18 ]

See also in sourсe #XX -- [ Pg.150 ]

See also in sourсe #XX -- [ Pg.317 ]



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Trypanothione disulfide

Trypanothione reductase

Trypanothione reductase, inhibition

Trypanothione synthesis

Trypanothione synthetase

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