Trovafloxacine

A number of quinolones had to be taken off the market due to toxic effects on the liver, heart, or other organs, that became recognized only after marketing (e.g. temafloxacin, trovafloxacin, grepafloxacin). A risk for severe cardiotoxicity, hepatotoxicity, or phototoxicity is... 

C11H5NO2 1631-26-1) see Trovafloxacin mesilate benzylmalonic acid (C]i)H,o04 616-75-1) see Acetorphan benzyl mercaptan... 

CH4O3S 75-75-2) see Alatrofloxacin mesilate Alendronate sodium Dolasetron mesilate Glaziovine Nelfinavir mesylate Tirilazad mesilate Trovafloxacin mesilate... 

This reaction is used for a total synthesis of trovafloxacin (Scheme 5.18).120... 

Trovafloxacin is a new and powerful antibiotic that is active against a wide variety of microor-121... 

This class of compounds comprises a series of synthetic agents patterned after nalidixic acid, a naphthyridine derivative introduced in 1963 for the treatment of urinary tract infections. Isosteric heterocyclic groupings in this category include the quinolones (e.g., norfloxacin, ciprofloxacin, lome-floxacin, gatifloxacin, sparfloxacin, moxifloxacin, and ofloxacin), the naph-thyridones (e.g., nalidixic acid, enoxacin, and trovafloxacin), and the cin-nolones (e.g., cinnoxacin) [2] (Fig. 1). 

Trovafloxacin Trovan Antibiotic Liver/kidney damage 1992 U.S. 1999 (use 7... 

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