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Troubleshooting of HPLC-ED Methods

Optimisation of an HPLC system for a specific analysis can be a complex task and many additional factors must be considered when using EC detection. These can be divided into system dependent variables and analyte dependent variables. System dependent variables include the nature of the working, reference and auxiliary electrodes and associated electronics, and the applied potential as discussed in Chapters 2 and 3. In addition, there may be influences from the eluent (solvent composition, pH, ionic strength), temperature and flow-rate. Analyte-dependent variables are specifically the presence of one or more electroactive moieties or functional groups on the compound(s) of interest. With compounds which are not inherently electroactive it may be possible to derivatise them, or to chemically modify them in some other way, to impart electrochemical properties. [Pg.56]

Development and Troubleshooting of HPLC-ED Methods Table 4.3 (Continued)... [Pg.73]

See other pages where Troubleshooting of HPLC-ED Methods is mentioned: [Pg.56]    [Pg.57]    [Pg.59]    [Pg.61]    [Pg.63]    [Pg.65]    [Pg.67]    [Pg.69]    [Pg.71]    [Pg.75]    [Pg.56]    [Pg.57]    [Pg.59]    [Pg.61]    [Pg.63]    [Pg.65]    [Pg.67]    [Pg.69]    [Pg.71]    [Pg.75]   


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