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TRNA transglycosylases

Brenk R, Meyer EA, Reuter K, Stubbs MT, Garcia GA, Diederich E, Klebe G. Crystallographic study of inhibitors of tRNA-guanine transglycosylase snggests a new structure-based pharmacophore for virtual screening. J Mol Biol 2004 338 55-75. [Pg.422]

Fig. 4.6 Example for successful structure-based virtual screening to identify submicromolar tRNA-guanine transglycosylase (TGT) inhibitors based on X-ray structures ofweaker ligands. Fig. 4.6 Example for successful structure-based virtual screening to identify submicromolar tRNA-guanine transglycosylase (TGT) inhibitors based on X-ray structures ofweaker ligands.
The enzyme tRNA-guanine transglycosylase (TGT) catalyzes the complete exchange of a base in tRNA [25, 26]. Upon reaction, guanine in the wobble position of tRNAs with the anticodon sequence GUN is replaced by the modified bases... [Pg.177]

Romier, C., Ficner, R., Suck, D. Structural basis of base exchange by tRNA guanine transglycosylase. In Modification and Editing of RNA, ASM Press, Washington, DC, 1998, pp. 169-182. [Pg.192]

Durand, J.M., Okada, N., Tobe, T., Watar-ai, M., Fukuda, I., Suzuki, T., Nakata, N., Komatsu, K., Yoshikawa, M., Sasakawa, C. vacC, a virulence-associated chromosomal locus of Shigella flexneri, is homologous to tgt, a gene encoding tRNA—guanine transglycosylase (TGT) of Escherichia coli K-12. J. Bacteriol. 1994, 176, 4627-4634. [Pg.192]

Romier, C., Meyer, J.E., Suck, D. Slight sequence variations of a common fold explain the substrate specificities of tRNA-guanine transglycosylases from the three kingdoms. FEBS Lett. 1997, 416, 93-98. [Pg.192]

Brenk, R., Stubbs, M.T., Heine, A., Reuter, K., Klebe, G. Flexible adaptations in the structure of the tRNA modifying enzyme tRNA-guanine transglycosylase and their implications for substrate selectivity, reaction mechanism and structure-based drug design. ChemBiochem 2003, 4, 1066-1077. [Pg.192]

J.D., Garcia, G.A., Reuter, K., Klebe, G. From hit to lead de novo design based on virtual screening hits of inhibitors of tRNA-guanine transglycosylase, a putative target of shigellosis therapy. Helv. Chim. Acta 2003, 86, 1435-1452. [Pg.192]

Meyer, E.A., Brenk, R., Castellano, R.K., Furler, M., Klebe, G., Dietrich F. De novo design, synthesis and in vitro evaluation of inhibitors for prokaryotic tRNA-guanine transglycosylase a dramatic sulfur effect on binding affinity. ChemBiochem 2002, 3, 250-253. [Pg.192]

Zymomonas mobilis tRNA guanine transglycosylase IPOB Cys 1 CySba 2 CySa 25 HiSa... [Pg.5158]

Tiiiodotbyiwiine (731, 733-734, 826 Tiimelhyllysiiie, 224-225 Tripalinitatc, chemical structure, 23 tRNA (transfer RNAJ, 34,38 tRNA-guaninc transglycosylase, 150 Tropical oils, 362 Tropical sprue, 152 Tidponin, 790,793 Trypsin, 63,88... [Pg.1004]

See other pages where TRNA transglycosylases is mentioned: [Pg.417]    [Pg.419]    [Pg.417]    [Pg.419]    [Pg.378]    [Pg.403]    [Pg.405]    [Pg.401]    [Pg.92]    [Pg.1456]    [Pg.1621]    [Pg.719]    [Pg.192]    [Pg.192]    [Pg.192]    [Pg.5158]    [Pg.327]    [Pg.150]    [Pg.625]    [Pg.633]    [Pg.416]    [Pg.683]    [Pg.686]    [Pg.712]    [Pg.734]    [Pg.543]    [Pg.708]    [Pg.5157]    [Pg.522]    [Pg.687]    [Pg.279]    [Pg.280]    [Pg.284]   


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TRNA

TRNA guanine transglycosylase inhibitors

TRNA-guanine transglycosylase

Transglycosylase

Transglycosylases

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