Triton mixed with other surfactants

A two-microemulsion method was employed by Chhabra et al. [266] for synthesis of titania particles. A surfactant, Triton X-100 and a co-surfactant, n-hexanol were mixed with cyclohexane, the oil phase, to obtain reverse micelles. In one of these, an aqueous solution of titanium tetrachloride (0.3M) formed the microemulsion core in the other, an ammonia solution was added. The two microemulsions thus obtained were mixed under vigorous stirring at room temperature to start a precipitation reaction leading to the formation of hydroxide precursor particles. The particles were collected by centrifugation and washed with chloroform and methanol. The anatase particles obtained at 700°C had a size... 

The compounds triisobutyl (methyl) phosphonium tosylate (a) and trihexyl (tetradecyl) phosphonium bis 2,4,4-(trimethylpentyl)phosphinate (b) were synthesized (Fig. 4.14), and their surface-active properties studied.The polar compound (a) is water soluble and surface active, does not form micelles, but affects the micelliza-tion properties of ionic, nonionic, and zwitterionic surfactants more strongly than conventional electrolytes. The less polar compound (b) forms micelles and has very low aqueous solubility. Both compounds form mixed micelles with Triton X-100 nonionic surfactant in aqueous solution. Compound (a) replaces water to form microemulsions with isopropyl myristate as oil, stabilized by (b). Compound (a) showed a clear antitumor activity, for example, 5mg (a)mH in 0.9% NaCl solution caused 100% killing of Sarcoma-180 cell line in 1 h. More diluted solutions were still active 2.5 and 1 mg (a) mT caused 81 and 53% killing of the same cells, respectively. On the other hand, compound (b) was less active than (a) lOmg (b)mT in 0.9% NaCl solution caused 89% killing of Sarcoma-180 cell line in 2h. Note that the concentration of (b) employed was 33 times higher than its cmc (0.03 x 10" moll ). The efficiency of (a) with respect to (b) may be due to the fact that the former does not form micellar aggregates [89]. 

---