Tritium chemical synthesis

When specifically labelled compounds are required, direct chemical synthesis may be necessary. The standard techniques of preparative chemistry are used, suitably modified for small-scale work with radioactive materials. The starting material is tritium gas which can be obtained at greater than 98% isotopic abundance. Tritiated water can be made either by catalytic oxidation over palladium or by reduction of a metal oxide ... 

Clearly the most elegant chemical synthesis of chiral acetate is the route reported by Townsend et al. (33). The method, outlined in Scheme 2, has the advantage that tritium is introduced at a late stage in the synthesis, and both of the remaining steps, pyrolysis and Kuhn-Roth oxidation, proceed in high... 

Radiolabelled compounds are prepared by introducing artificially produced (nuclear reactor, cyclotron) radioisotopes into the molecules. This can be accomplished by chemical synthesis, biosynthesis and by special procedures (e.g. isotopic exchange, reduction of an unsaturated precursor with tritium gas). As a rule the choice of the preparation method greatly affects the principal characteristics of the radioactive product such as specific activity, type of labelling and purity... 

Preparation of Tritium-Labeled Compounds by Chemical Synthesis... 

Preparation of Tritium-Labeled Compounds by Chemical Synthesis 111 4.1.1 Tritiation of Carbon-Carbon Multiple Bonds... 

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