Triterpenoids tumor growth

As shown in Fig. (5) , primary tumor cells in the spleen grew and invaded the while and red pulp of the spleen in mice with intrasplenically implanted LLC. The orally administered triterpenoid fractions (100 or 200 mg/kg) prevented the tumor growth and the invasion of the white pulp of the spleen. Furthermore, the orally administered triterpenoid fractions induced an accumulaiion of lymphocytes around tumor cells in the white pulp of the spleen Fig. (5) . The metastatic tumor cells in the liver also grew and invaded the hepatocytes in mice with intrasplenically implanted... 

Many of these terpenoids have been reported to be biologically active as indicated in Table 1, although such work has occurred on these compounds when isolated as constituents of plant families other than the Dipterocarpaceae [68-81]. For example, the common triterpenoid, betulinic acid (21), was reported as having selective cytotoxic activity for several human melanoma cell lines, and also demonstrated highly effective tumor growth inhibition in athymic (nude) mice with human melanoma cells at non-toxic doses [72]. 

LLC. The growth of the metastatic tumor cells was prevented by the orally administered triterpenoid fractions Fig. (6a) . Lymophocytes in the liver also accumulated around the metastatic tumor cells Fig. (6b) . 

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