Triterpene glycosides immunomodulatory activities

Triterpene glycosides of sea cucumbers demonstrate a wide spectrum of biological effects antifungal, antitumor, hemolytic, cytostatic and immunomodulatory activities [12]. The application of many preparations from sea cucumbers in traditional oriental medicine has been reported [13]. The medicinal properties of these sea food preparations are attributed to triterpene glycosides [13]. 

The crude holothurin from A. agasssizi stimulated hemopoesis in bone marrow of frog [24]. A minimal immunomodulatory dose (0.05 p-g/kg) of crude cucumarioside from Cucumaria japonica induced delay of rat liver cell mitosis 28 to 32 hours after hepatoectomy but after 40 to 44 hours induced the compensatory increase in mitotic activity [94]. The authors concluded that the triterpene glycosides affect the regulation of proliferative processes. 

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