Triptolide biological activity

ABSTRACT This article reviews the literature published dealing with the synthesis of some bioactive diterpenes. It describes the biological activity and synthesis of only four diterpenes pisiferic acid, camosic acid, triptolide and miltirone. This review excludes the discussions of Taxodione, a bioactive diterpene, because it has already been reviewed [85], The utility of several reagents in the total synthesis of terpenoid compounds has been documented. It can be observed that several routes have been developed for the synthesis of a single diterpene. 

Tripelennamine as antihistamine, 1, 177 biological activity, 4, 911 toxicity, 4, 912 Tripelennamine, p-bromo-as antihistamine, 2, 520 a-Tripiperideine synthesis, 3, 510 Triprolidine as antihistamine, 1, 177 Triptolide, 7, 192 Tripyrroles synthesis, 4, 415, 416 1,6,6a A4-T riselenapentalenes CNDO calculations, 6, 1052 PE spectra, 6, 1057 Trisilacyclobutanes synthesis, 1, 601... 

The chemistry of components from the TW plant has been well characterized. The biological activity of these components is under study for the development of clinically useful therapeutic agents. Among the components, triptolide type compounds are being developed for treatment of autoimmune diseases as well as cancer, and other components such as celastrol-type compounds and alkaloids also have prospects for further development. All of these are examples derived from the investigation of Traditional Chinese... 

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