Triple-quadrupole quantum

Another type of commercially available triple-quadrupole known as the TSQ Quantum was recently reported100 to achieve significantly better resolution than a traditional triple quadrupole instrument without any significant loss of transmission. Based on the improved inherent resolution, assay development of an analyte on a classic TSQ that requires extensive sample preparation... 

Figure 1.9. Triple-stage quadrupole Quantum mass spectrometer capable of operating under enhanced resolution conditions. To reduce the chemical noise and to improve the sensitivity, the mass analyzers were oriented in an L shape rather than the conventional straight design. An additional benefit of the L shape orientation is a smaller foot print. (Courtesy of ThermoFisher Scientific.)...

LC-MS experiments were performed using an ion trap (LCQ Classic, Thermo Electron Corp., San Jose, CA) or triple-quadrupole (TSQ Quantum, Thermo Electron Corp., San Jose, CA) mass spectrometers. The experimental conditions are summarized below ... 

Figure 9.Z LC-ESI-MS spectra ofDL, 6-OH-DL, 3-OH-DL, N-OH-DL, and 1-pyridine-U-oxide-DL generated using a TSQ Quantum triple-quadrupole mass spectrometer.

LC-MS/MS System Used and Analytical Conditions An LC system from Thermo Finnigan, USA was used. The system consisted of a quaternary pump (Surveyor series) and an Autosampler (Surveyor series, equipped with a temperature controlled tray and a column oven), connected to a TSQ-Quantum triple quadrupole mass spectrometer, supplied with an electrospray ion source (Thermo Finnigan, San Jose, CA, USA). 

The HPLC system was coupled with Finnigan TSQ Quantum triple quadrupole mass spectrometer (Thermo Fisher). The mass spectrometer was operated in positive... 

Figure 4.7 Two-dimensional mass spectrometric analysis of polyunsaturated fatty acid fragmentation pattern with variation of collision-gas pressure. MS analysis was performed with a TSQ Quantum Ultra Plus triple-quadrupole mass spectrometer (Thermo Fisher Scientific, San Jose, CA) equipped with an automated nanospray apparatus (i.e.. Nanomate HD, Advion Bioscience Ltd., Ithaca, NY) and Xcalibur system software. Product-ion scan of 8,11,14-eicosatrienoic acid (20 3 FA) (5 pmol/pL) was performed after direct infusion in the negative-ion mode at the fixed collision energy of 16 eV and varied collision-gas pressures ranging from 0 to 3 mTorr as indicated. A 2-min period of signal averaging in the profile mode was employed for each scan. All the scans were automatically acquired with a customized sequence subroutine operated under Xcalibur software. All the scans are displayed after being amplified to the 5% of the base peak in each individual scan.

Figure 2.236 Curved collision cell of a triple quadrupole system (90°) for reduction of nonspecific noise by eliminating neutral particles and photons from the ion flight path. (TSQ Quantum series, courtesy Thermo Fisher Scientific.)...

The resolution of a quadrupole is not only determined by the ratio of DC and RF, but also by the quality and the alignment of the rods. The potential of enhanced resolution in a quadrapole mass filter was investigated by Tyler et al. [33], Enhanced resolution leads to a significant loss in response. Recently, Thermo Fiimigan introduced a triple-quadrapole instrument with improved quadrapole design, RF power supply stability, and temperature control (TSQ Quantum), enabling 0.1-unit-mass resolution without dramatic losses in response [34]. 

Solid-state Na NMR parameters of Na montmorillonite under dry and hydrated conditions have been measured to study hydration structure of Na in interlayer spaces. The Na triple quantum MAS NMR experiments have been performed to determine the quadrupole coupling constants Cq and the isotropic chemical shifts, 8 so- The Cq values were found to remarkably depend on water content, i.e. the Cq values increase with changing from dry condition to hydrated one and gradually decrease with an increase in the water content. Since the Cq value is a sensitive parameter to the local structure of the nucleus measured, the changes in Cq values with water content should correspond to those in the hydration structure of Na+ in the interlayer spaces. Thus, it was considered that the increment of the Cq value is due to the formation of hydrated Na with planar structure, and that the decrease in Cq values with the water content is attributed to the formation of hydrated Na with spherical symmetric structure. 

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