Trimipramine side effects

Trimipramine is a tricyclic antidepressant with sedative properties that is used in the management of depression. As with other tricyclic antidepressants, trimipramine has antimuscarinic activity and therefore side-effects include dry mouth, blurred vision, constipation and urinary retention. 

Imipramine, amitriptyline, clomipramine, trimipramine, and doxepin are tertiary amine TCAs. Desipramine, nortriptyline, and protriptyline are secondary amine TCAs. Tertiary amine tricyclics have more potent serotonin reuptake inhibition, and secondary amine tricyclics have more potent noradrenergic reuptake inhibition. Tertiary amine TCAs tend to have more side effects than do... 

Imipramine, amitriptyline, doxepin, desipramine, clomipramine, and trimipramine therapy can be initiated at 25-50 mg/day. Divided dosing may be used at first to minimize side effects, but eventually the entire dose can be given at bedtime. The dose can be increased to 150 mg/day the second week, 225 mg/day the third week, and 300 mg/ day the fourth week. The dose of clomipramine should not exceed 250 mg/day because of an increased risk of seizures at higher doses. 

Antidepressants with sedation as a side effect often are used to treat insomnia. The antidepressants most frequently associated with sedation as a side effect are the tricyclics (amitryptyline, imipramine, nortriptyline, trimipramine, doxepin, amoxapine, and protriptyline), nontricyclics (maprotiline and mirtazepine), trazodone, and nefazodone (55), which are discussed in greater detail in Chapter 21. Of these drugs, trazodone, doxepin, and mirtazepine have been shown to be effective in the treatment of insomnia in patients with depression (1). The effectiveness of these drugs to treat insomnia in nondepressed patients, however, has not been proven. The mechanism by which this occurs is unknown, but most of these drugs have some activity as H2 antagonists that may contribute to the effect (56). 

Tricyclic antidepressants (TCAs) Clomipramine Doxepin Imipramine Lofepramine Nortriptyline Trimipramine (Amitriptyline, Dosulepin) Nocte See BNF See BNF See BNF For depression clomipramine used in OCD Liquids and tablets available Very toxic in overdose (amitriptyline and dosulepin no longer recommended for depression due to OD risk) Caution in CVD and many physical conditions Tolerance to side effects may develop Anticholinergic side effects ... 

Trimipramine Propyl side-chain Little effect on monoamine re-uptake... 

Such in-situ generated adsorption isotherms indicate different extents of surface coverage. The latter was estimated from controlled-adsorption/-cyclic voltammetric experiments. Values of 3.9 x 10 i , 5.9 x 10 , and 8.6 X 10-10 mol/cm2 (corresponding to 43, 32, and 19 nm /adsorbed molecule) were calculated for desipramine, imipramine, and trimipramine, respectively. It appears that minor differences in the side chain of antidepressants have a profound effect upon their orientation imipramine and desipramine yield the expected planar orientation of the tricyclic ring system and the carbon surface, while for trimipramine a vertically oriented adsorbed layer is indicated. Adsorption isotherms may be useful also for obtaining information regarding intermolecular interactions between absorbed molecules, as well as on interactions between adsorbed molecules and the surface. Concentration-induced orientational transitions may also be detected from the construction of adsorptive stripping calibration curves. 

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