Trimethoprim-sulphamethoxazole

Nakai, H. Takasuka, M. Shiro, M. X-ray and infrared spectral studies of the ionic structure of trimethoprim-sulphamethoxazole 1 1 molecular complex. J. Chem. Soc., Perkin Trans. 1984, 11, 1459-1464. 

Dornbusch K, Toivanen P. Effect of trimethoprim or trimethoprim/sulphamethoxazole usage on the emergence of trimethoprim resistance in urinary tract pathogens. Scand J Infect Dis 1981 13(3) 203-10. 

Salter, A. J., The toxicity profile of trimethoprim/sulphamethoxazole after four years of wide-spread use. Med. J. Aust. 1 (Suppl.), 70-74 (1973). 

Prophylaxis against Pneumocystis carinii, classified as a fungus although in many ways it behaves more as a protozoal infection, should be with trimethoprim-sulphamethoxazole. However, it should be borne in mind that this can cause bone marrow suppression in its own right. 

Trimethoprim + Sulphamethoxazole Treatment/prophylaxis of Pneumocystis carinii pheumonia. First attack of Urinary Tract Infections (UTIs). 

The combined use of natural-abundance solid state and NMR has shown that the structure of the trimethoprim sulphamethoxazole complex (TMP SMZ) is best described by transfer of the proton N(7) of SMZ (12) to N(l) of TMP (13). 

JakobsonB, Nilsson A, Methemoglobinemiaassociatedwitiiaprilocaine-lidocainecream and trimethoprim-sulphamethoxazole. A case report. Acta AnaesthesiolScand( 9S5) 29,453-55. 

Sjoberg S, Wiholm BE, Gunnarsson R, Emilsson H, Thunberg E, Christenson I, Ostman J. Lack of pharmacokinetic interaction between glibenclamide and trimethoprim-sulphamethoxazole. DiabetMed 9S7) 4, 245-7. 

The combination of a sulphonamide with trimethoprim (Wellcome and Roche, 1968), an inhibitor of microbial dihydrofolate reductase, blocks two steps in the synthesis of tetrahydrofolate and leads to a synergistic antibacterial effect. Trimethoprim sulphamethoxazole combinations (Figure 4.22) continue to play an important role in antibacterial therapy (Table 4.4) but as a... 

A 41-year-old woman with systemic lupus erythematosis developed methemoglobinemia 2 days following administration of trimethoprim-sulphamethoxazole (40/400mg) for prophylaxis of pneumocystis pneumonia [139 ]. 

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