Trimethoprim-sulfamethoxazole allergic reactions

Richmond JM, Whitworth JA, Eairley KE, Kincaid-Smith P. Co-trimoxazole nephrotoxicity. Lancet. 1979 Mar 3 1 (8114) 493. Kraemer MJ, Kendall R, Hickman RO, Haas JE, Bierman CW. A generalized allergic reaction with acute interstitial nephritis following trimethoprim-sulfamethoxazole use. Annals of allergy. 1982 Dec 49(6) 323-5. 

Allergic reactions in the liver can be caused by many drugs and result in many different kinds of hepatic damage. Trimethoprim-sulfamethoxazole and penicillinase-resistant penicillins such as... 

Kraemer MJ, Kendall R, Flickman RO, Flass JE, Bierman CW. A generalized allergic reaction with acute interstitial nephritis following trimethoprim-sulfamethoxazole use. Ann Allergy 1982 49 323-325. 

Wahlin and Rosman (1976) observed eight cases of serious skin and general reactions within 18 months after cotrimoxazole which were based on allergic reactions. Braun-Falco et al. (1978) observed pustulosis acuta generalisata with distinct leukocytoclastic vasculitis in the upper corium in a 52-year-old woman who was treated with trimethoprim/sulfamethoxazole for acute bronchitis. 

Studies have been few but the diagnostic procedures applied so far for trimethoprim and sulfamethoxazole, and the immunochemical defliution of the drug allergenic determinants, have provided a firm basis for the clinician to confidently diagnose and distinguish immediate allergic reactions to these two drugs. 

Naitoh T, Yamamoto M, Kawakami K, Suzuki C, Naishiro Y, Yamamoto H, Takahashi H, Shinomura Y. Case of systemic lupus erythematosus repeated with various allergic reactions by trimethoprim-sulfamethoxazole. Nihon Rinsho Meneki Gakkai Kaishi 2009 32(6) 492-8. 

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