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Triglycerides Orlistat

Lipase Inhibitor Orlistat (Xenical, Roche) is prescribed for the treatment of obesity. It inhibits the gastrointestinal lipase enzymes by binding to the lipase through the serine site and inactivates the enzyme. Fat in the form of triglycerides cannot be hydrolyzed by the lipase and converted to free fatty acids and monoglycerides. Thus, there is no uptake of fat molecules into the cell tissue. [Pg.36]

In 1987, scientists at Hoffmann-La Roche described their discovery of hpstatin (5), a secondary metabolite isolated from Strptomyces toxytricini, and demonstrated that it is a potent inhibitor of pancreatic lipase.Simple hydrogenation of 5 formed terahydrolipstatin (1,USAN, orlistat) which possesses comparable biological activity but is more stable than 5. Orlistat (1, Xenical ) works through pancreatic lipase inhibition. Pancreatic lipase is the key enzyme of dietary triglyceride absorption, exerting its activity... [Pg.150]

Orlistat inhibits pancreatic lipase and can block 30% of triglyceride hydrolysis in subjects eating a 30% fat diet. [Pg.155]

Orlistat (Fig. 20.7) is the only Gl tract dmg indicated in the BNF, and is a lipase inhibitor, which reduces fat intake. This dmg is a synthetic analogue of lipstatin which is a namrally occurring substance produced by Streptomy-ces toxytricini. Orlistat is an iueversible inhibitor of pancreatic and gastric lipases and as such it prevents these lipases from breaking down triglycerides into their absorbable form (free fatty acids and monoglycerols). The triglycerides are thus eliminated without absorption and thus there is a decreased dietary intake of fat. [Pg.400]


See other pages where Triglycerides Orlistat is mentioned: [Pg.160]    [Pg.161]    [Pg.161]    [Pg.1534]    [Pg.39]    [Pg.47]    [Pg.160]    [Pg.160]    [Pg.161]    [Pg.161]    [Pg.1023]    [Pg.631]    [Pg.843]    [Pg.216]    [Pg.217]    [Pg.222]    [Pg.2668]    [Pg.590]    [Pg.937]   
See also in sourсe #XX -- [ Pg.31 , Pg.437 ]




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