Triflupromazine hydrochloride

Triflupromazine and Triflupromazine Hydrochloride are discontinued from the market. 

Triflupromazine Hydrochloride is l0-/ 3- (Dimethylamino) -propyjJ -2-trifluromethylphenothiazine hydrochloride also luoromethyjJ ... 

Triflupromazine hydrochloride occurs as a white to pale tan, crystalline powder, with a slight characteristic odor. 

Figure 1. I.R. Spectrum of Triflupromazine Hydrochloride. Squibb Standard 48241-003. Mineral oil mull. Instrument Perkin-Elmer 21.

The NMR spectrum of triflupromazine hydrochloride is presented in Figure 3. The N-methyl proton resonances are seen as two singlets. 

Triflupromazine hydrochloride is very water soluble and hygroscopic. 

Triflupromazine hydrochloride is hygroscopic. When moisture is excluded it is stable in the... 

The precipitate with silicotungstic acid has been used for the quantitative determination of triflupromazine hydrochloride in tablets. 

N H2SO4). The electrochemistry of triflupromazine in acetonitrile has also been studied. Polarographic evidence has been presented to prove the complexation of of triflupromazine hydrochloride with oxygen. 

A titrimetric method has been reported in which triflupromazine hydrochloride was titrated visually to a colorless endpoint with ceric sulfate. The reaction proceeds through forming a red-colored semiquinone free radical (420 nro ) followed by formation of the colorless sulfoxide derivative. The method can be applied to pharmaceutical dosage forms. 

The ultraviolet absorption maximum at 255 nm has been used for a quantitative assay of triflupromazine hydrochloride in formulations. 

Triflupromazine hydrochloride, like other phenothiazine drugs exhibits fluorescence. This phenomenon was first explored in 0.2N sulfuric acid. The fluorescence peak was found in the range of 450 to 475 nm, shifting to slightly lower wavelength upon oxidation with potassium permanganate. As little as 0.01 to 0.05 [j,g of the pure substance per ml. of 0.2N sulfuric acid could be detected. Due to interference by other substances, the sensitivity in biological fluids was lower (about 0.8 i,g/ml of fluid). 

Electrophoresis in various buffers, proposed by Wernum was carried out on triflupromazine hydrochloride and several other phenothiazine tranquillizers. A Gordon-Misco apparatus, Whatman 3MM paper 30 cm in width, and a potential difference of 500 to 800 volt was used. Detection of spots was carried out with a 40% sulfuric acid spray (orange color) or... 

For triflupromazine hydrochloride, anodic migration (cm) after 40 to 60 minutes was ... 

Many of the references cited in previous sections concern methods devised to identify and determine triflupromazine hydrochloride and other phenothiazines for pharmacological, toxicological and forensic purposes (cf. 45). These methods can be classified as follows ... 

Propiomazine Hydrochloride, 2,439 Propoxyphene Hydrochloride, 7, 301 Sodium Cephalothin, 7,319 Sodium Secobarbital, 7, 343 Sulfamethoxazole, 2,467 Sulfisoxazole,2, 487 Triamcinolone, 7,367 2,571 Triamcinolone Acetonide, 7,397 2,571 Triamcinolone Diacetate, 7,423 Triclobisonium Chloride, 2, 507 Triflupromazine Hydrochloride, 2, 523 Trimethobenzamide Hydrochloride, 2, 551... 

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