Triflupromazine

Chemical Name N,N-Dimethyl-2-(trifluoromethyl)-1 OH-phenothiazine-10-propanamine Common Name Fluopromazine 

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C5H12CIN 109-54-6) see Acepromazine Bencyclane Benzydamine Chlorpromazine Citalopram Clomipramine Dimetacrine Imipramine Promazine Prothipendyl Triflupromazine... 

Traube purine synthesis, 423 Triamcinolone, 201 Triamcinolone acetonide, 201 Triamterine, 427 Triazines, synthesis, 280 Triazolam, 368 Trichlomethiazide, 359 Trichomonas, 238 Tricyclic antidepressants, 149 Trifluoperidol, 306 Trifluoromethyl group, potentiation of biologic activity, 380 Triflupromazine, 380, 381 Trihexyphenidil, 47 Triiodothyronine, 95 Trimeprazine, 378 Trimethadione, 232 Trimethobenzamide, 110 Trimethoprim, 262 Trioxsalen, 334 Tripelenamine, 51 Triprolidine, 78 Tropinone, 5 Tropocaine, 7 Truth serum, 274... 

From the chemical point of view antipsychotic drugs are subdivided into six chemical groups, as well as to the group of non-classifiable drugs. They are phenothiazines (chlorpromazine, promazine, triflupromazine, acetophenazine, fluphenazine, perphenazine, prochlorpherazine, trifluoperazine, mesoridazine, and thioridazine), thioxanthenes... 

This group of drugs is subdivided into three subgroups depending on the type of substitution on the nitrogen atom of the phenothiazine ring. The subgroups are phenothiazines with an aliphatic side chain (chlorpromazine, promazine, triflupromazine), piperazine derivatives (acetophenazine, fluphenazine, perphenazine, prochlorperazine, trifluoperazine), and piperidines (mesoridazine, thioridazine). 

Triflupromazine Triflupromazine, 2-trifluoromethyl-10-(3-dimethylaminopropyl) phe-nothiazine (6.1.3), also is synthesized by the alkylation of 2-trifluoromethylphenothiazine using 3-dimethylaminopropylchloride in the presence of sodium amide [7-12],... 

In psychiatric practice, triflupromazine is used for psychomotor excitement in patients with schizophrenia for paranoid and manic-depressive conditions, and for neurosis. The most common synonym is vesprin. 

Phenothiazines are also nonspecific dopaminergic antagonists and are an old family of neuroleptics. However, they are less and less used (fluphenazine, oxa-flumazine, trifluoperazine, triflupromazine). Flupenthixol and isofloxythepine are recent neuroleptics that can be grouped with phenothiazines (Figure 8.29). 

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