TRIESTE,UNIVERSITY

This review was written in part at the University of Trieste. The author is indebted to Dr. (Miss) M. Forchiassin and to Mrs. G. Fabris for valuable assistance in the preparation of the typed manuscript and to many others of the staff for computation work and for a critical reading of the paper. 

We acknowledge support from INAF-PRIN 2002 (PI Dr. Bertelli), from University degli Studi di Trieste (ex 60% grants) and from MIUR COFIN-2003028039. 

University of Trieste, Italy Email daros units.it... 

Dr. Tatiana Da Ros Dipartimento di Scienze Farmaceutiche University of Trieste Piazzale Europe, 1-34127 Trieste, Italy... 

University of Trieste Chemistry Department Center of Excellence for Nanostructured Materials (CENMAT) and INSTM-Trieste Research Unit Via L. Giorgieri 1 34127 Trieste Italy... 

Erwin Lijnen (183), Division of Quantum Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium Edwin Lo (13), Henry A. Rowland Department of Physics and Astronomy, The Johns Hopkins University, Baltimore, MD 21218, USA Martin Liiders (289), International School for Advanced Studies (SISSA), Via Beirut 4, 34014 Trieste, Italy and INFM Democritos National Simulation Center, and INFM, Unita Trieste, Italy... 

Laszlo Otvos, Jr. Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, PA Marco Scocchi Department of Life Sciences, University of Trieste,... 

Acknowledgements This work was carried out with partial support from the University of Trieste (Fondi ex 60%),MIUR (cofin prot.MM03198284), the European Union, RTN program WONDERFULL (HPRN-CT-2002-00177)... 

In collaboration with University of Trieste, we have developed rational approaches for the design and synthesis of peptidomimetic and non-peptidic inhibitors of HIV PR, utilizing structure-based [12-15], as well as combinatorial, library design methods [16, 17]. In this paper, we survey computer-assisted studies on the design, focusing and in silico screening of virtual combinatorial libraries of peptidomimetics and cyclic ureas, as potential anti-HIV agents, that were carried out in our laboratory. 

Valerie J. Gillet University of Sheffield Sheffield, United Kingdom Vladimir Frecer International Centre for Science and High Technology Trieste, Italy... 

A. Schuchardt,. Thesis. (DICAMP, University of Trieste, Italy) 1995, in press. 

Dipartimento di Scienze Chimiche, Universita degli Studi di Trieste, Via Licio Giorgieri 1, 34135 Trieste, Italy Division of Organic Chemistry 3, Chemical Center, University of Lund, P.O. Box 124, S-22100 Lund, Sweden The Beverly and Raymond Sackler Faculty of Exact Sciences, School of Chemistry, Tel-Aviv University, Ramat-Aviv, Tel-Aviv 69978, Israel Department of Synthetic Chemistry, Kyoto University, Kyoto 606-01, Japan... 

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