Trididemnum Shermilamines

The shermilamines constitute a group of alkaloids characterized by a thiazinone ring attached to the pyridoacridine ring system. Shermilamine A (36) was the first known compound of this series and was isolated by Scheuer et al. from the tunicate Trididemnum sp. [38]. The complete... 

Shermilamines A and B were isolated from a purple Trididemnum sp. [146,147], while shermilamine C was reported from a purple fleshy Cystodytes sp. from Fiji [132]. Both shermilamines A and B were reported in a paper which described metabolites from Amphicarpa meridiana and Leptoclinides sp. [145], while shermilamine B was also reported under the name debromoshermilamine from a Red Sea Eudistoma sp, [135]. Biosynthetic studies on shermilamine B have been reported [150]. The... 

Carroll AR, Cooray NM, Poiner A, Scheuer PJ (1989) A second shermilamine alkaloid from a tunicate Trididemnum sp. J Org Chem 54 4231-4232 Cheng J-f, Ohizumi, Walchli MR, Nakamura H, Hirata Y, Sasaki T, Kobayashi J (1988) Prianosins B, C, and D, novel sulfur-containing alkaloids with potent antineoplastic activity from the Okinawan marine sponge Prianos melanos. J Org Chem 53 4621-4624... 

---