Amphicarpa meridiana

Pentacyclic aromatic alkaloid Amphicarpa meridiana CHCl3-MeOH-5% HCl (5 5 3) HSCCC... 

Shermilamines A and B were isolated from a purple Trididemnum sp. [146,147], while shermilamine C was reported from a purple fleshy Cystodytes sp. from Fiji [132]. Both shermilamines A and B were reported in a paper which described metabolites from Amphicarpa meridiana and Leptoclinides sp. [145], while shermilamine B was also reported under the name debromoshermilamine from a Red Sea Eudistoma sp, [135]. Biosynthetic studies on shermilamine B have been reported [150]. The... 

CI gHjNsOj, Mr 299.29, an alkaloid (both tautomers iso-lable) from the ascidian Amphicarpa meridiana, yellow solid, mp. >250°C, with antifungal activity. 

Meridine is an alkaloid of pyridoacridine and has been found in sponges and in tunicates (Molinski, 1993). Isolated in 1991 from the Australian ascidian Amphicarpa meridiana, this antifungal compound was found the following year in an undetermined species of the genus Corticium, harvested in the Bahamas. In the current state... 

Schmitz, F.J., DeGuzman, F.S., Hossain, M.B., and Van der Helm, D. (1991) Cytotoxic aromatic alkaloids from the ascidians Amphicarpa meridiana and Leptodinides sp. meridine and 11-hydroxy-ascididemnin. J. Org. Chem., 56, 804-808. 

Related to pyridoacridines, meridine is a pentacydic alkaloid from the spedes Amphicarpa meridiana, isolated with a stable tautomer it is cytotoxic to P388 cells, with an IC50 of about 0.4(xgml. ... 

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