Tricyclic xanthenes

In Section II.C we will present novel tricyclic xanthene derived amino acid templates, which allow the construction of libraries of cyclic conformationally constrained peptide loop mimetics using the split-and-mix method without having to use tagging and deconvolution strategies. In Section III we will focus on parallel and combinatorial approaches devoted to the synthesis of small molecule, non-peptidic compound collections, which in addition offer the possibility to incorporate structural features derived from protein epitope mapping into conformationally constrained peptide mimetics. 

Figure 2.3.5 shows a series of tricyclic xanthene-, phenoxazine- and phenothiazine-derived templates that have been shown to stabilise p-tum conformations in attached peptides for n=2 and 4.24 These templates were also successfully employed for the synthesis of larger loop mimetics (n S 14). 

Dibenzoparathiazine. See Phenothiazine Dibenzopyran, tricyclic. See Xanthene Dibenzo (a,b) pyrene-7,14-dione 2,3,7,8-Dibenzopyrene-1,6-quinone. See Vat yellow 4 2,3,5,6-Dibenzopyridine Dibenzo (b,c) pyridine Dibenzo (b,e) pyridine. See Acridine Dibenzopyrrole. SeeCarbazole Dibenzosuberan-5-one. See Dibenzosuberone Dibenzosuberone... 

CAS 92-83-1 EINECS/ELINCS 202-194-4 Synonyms Dibenzopyran, tricyclic 10H-9-Oxaanthracene 9H-Xanthene... 

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