Tricyclic Silicon Containing Compounds with Potential Psychotropic Activity

9 Tricyclic Silicon Containing Compounds with Potential Psychotropic Activity 

Compounds of type 117, containing a tricycyc nucleus with a six-or seven-mem-bered central ring A, a three atom aliphatic side chain (saturated or unsaturated, linear or branched) bound to the central ring A, and a basic functional group (ter- 

R = amino-substituted C3 side chain A - six— or seven—membcred ring 

In addition to the stereochemical structure of the tricyclic skeleton, the conformation of the amino-substituted side chain can influence the psychotropic activity of such compounds. According to the theory of Wilhelm, transmission of the basic psychotropic activity depends largely on the constellation adopted by the side chain. However, the main psychotropic action (neuroleptic or thymoleptic) is chiefly a function of the particular stereochemistry of the tricyclic framework. 

Some novel experimental results are in contradiction to the hypothesis of a stereochemical structure-activity relationship. Two research groups (Corey et al., Tacke, Wannagat et al.) are working independently from each other on silicon containing tricyclic compounds with potential psychotropic activity, to bring some light to this dilemma. 

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X-ray diffraction analyses of some tricyclic silicon containing compounds with potential psychotropic activity have been carried out93, 100, 101 The experimental dihedral angles a are summarized in Table 12. 

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