Trichothecene mycotoxins inactivation

The trichothecene mycotoxins are nonvolatile compounds produced by molds. They are very stable and resist heat- and ultraviolet light-induced inactivation. Only after heating at 500°F for 30 minutes will the toxins inactivate. 

When maintained as either crystalline powders or liquid solutions, trichothecene mycotoxin compounds are stable when exposed to air, light, or both. 35 44 Moreover, these mycotoxins are not inactivated by autoclaving but require heating at 900°F for 10 minutes or 500°F for 30 minutes for complete inactivation. A 3% to 5% solution of sodium hypochlorite is an effective inactivation agent for them.44 The efficacy of this solution can be increased by the addition of small amounts of alkali. 

The trichothecene mycotoxins are low-molecular-weight nonvolatile compounds produced by certain molds. They are not water soluble but are soluble in alcohols. They are very stable to heat and ultraviolet light but are inactivated by alkaline... 

Ueno, Y. and Matsumoto, H. (1975). Inactivation of some thiol-enzymes by trichothecene mycotoxins for Fusarium species. Chem. Pharm. Bulletin. 23, 2439-2442. 

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