Trichothecene mycotoxins excretion

Swanson, S.P., Corley, R.A. (1989). The distribution, metabolism and excretion of trichothecene mycotoxins. In Trichothecene Mycotoxicosis Physiological Effects, Vol. 1 (V.R. Beasley, ed.), pp. 37-61. CRC Press, Boca Raton, FL. 

Pharmacokinetic studies60,61 have demonstrated T-2 toxin in the plasma of animals that were administered this mycotoxin both intravascularly and by aerosol. As plasma concentrations of the parent trichothecene mycotoxin decrease, the deacylated and hydroxylated metabolites and their glucu-ronide conjugates rapidly appear and disappear from circulation. From these various observations, we can conclude that the pharmacokinetics of the trichothecene mycotoxins are functions of the rate of absorption into the general circulation, metabolism, tissue distribution, and excretion. 

Regardless of the route of administration or the species of animal tested, the trichothecene mycotoxins were rapidly metabolized and excreted in urine... 

In summary, then, very little of the parent trichothecene mycotoxin is excreted intact. Rather, elimination by detoxification of the toxin is the result of extensive and rapid biotransformation. 

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