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Tricarboxylic acid cycle acids

Busch et al. (B37) have determined most of the tricarboxylic acid cycle acids of rat kidney by ion exchange chromatography on Dowex 1. This technique has been used also in studies on liver mitochondria (Al), but has not been applied, to our knowledge, to organic acids in blood or urine. [Pg.59]

Gas chromatography, which has been applied to the separation of the tricarboxylic acid cycle acids in the liver (F8), might prove useful in the future in the field of organic acids of blood and urine. [Pg.59]

In the light of these findings, it is interesting to discuss the mechanism responsible for the elevation of the blood lactic and pyruvic acids as well as of the tricarboxylic acid cycle acids. [Pg.96]

Depending on the number and range of acids to be analysed, workers have used temperature conditions from limited isothermal to temperature-programmed runs. The latter are essentially mandatory to cover the tricarboxylic acid cycle acids in any acceptable time period and are employed almost exclusively unless specialized.analyses are required. [Pg.65]

The best polyester phase for separating methyl ester derivatives of Krebs cycle acids depends on several factors, but poly(ethylene glycol) adipate (PEGA) has been shown in one study (de Silva, 1971) to give the best separation and most stable baseline of the several phases tested. In this instance aim column of 5 per cent (w/w) PEGA on silanized Chromosorb P (100-120 mesh) support with column temperature programming from 80 to 180°C at 10°C min" separated all tricarboxylic acid cycle acids in addition to lactic and pyruvic acids within about 14 min. [Pg.67]

Progress in establishing GC methods for analysing aromatic acids has followed a very similar pattern to that of the tricarboxylic acid cycle acids. Although they are measured more frequently now in the presence of other acids, the aromatic acids have been given specific attention by a number of workers. [Pg.67]

Like the tricarboxylic acid cycle acids, the analysis of aromatic acids by GC has depended on the concurrent development of derivatization techniques and the availability of adequate liquid phases. Prior to 1966 methylation of the carboxylic acid group was the only reaction used to reduce the polarity of the compound sufficiently for passage through non-polar columns. Williams and his collaborators published several papers during this time (Sweeley and... [Pg.67]

Harmon, M.A. and Doelle, H.W. (1969), Gas chromatographic separation and determination of micro quantities of the esters of the tricarboxylic acid cycle acids and related compounds. J. Chromatogr., 42,157. [Pg.144]

Glutamic acid is formed m most organisms from ammonia and a ketoglutaric acid a Ketoglutaric acid is one of the intermediates m the tricarboxylic acid cycle (also called the Krebs cycle) and arises via metabolic breakdown of food sources carbohy drates fats and proteins... [Pg.1123]

The 4-phosphopantetheine group of CoA is also utilized (for essentially the same purposes) in acyl carrier proteins (ACPs) involved in fatty acid biosynthesis (see Chapter 25). In acyl carrier proteins, the 4-phosphopantetheine is covalently linked to a serine hydroxyl group. Pantothenic acid is an essential factor for the metabolism of fat, protein, and carbohydrates in the tricarboxylic acid cycle and other pathways. In view of its universal importance in metabolism, it is surprising that pantothenic acid deficiencies are not a more serious problem in humans, but this vitamin is abundant in almost all foods, so that deficiencies are rarely observed. [Pg.593]

Krebs, H. A., 1970. The hi.story of the tricarboxylic acid cycle. Perspectives in Biology and Medicine 14 154—170. [Pg.672]

Tricarboxylic acid cycle (Section 29.7) An alternative name for the citric acid cycle by which acetyl CoA is degraded to CO2. [Pg.1252]

Tributyltin hydride, reaction with alkyl halides. 358 Tricarboxylic acid cycle, see Citric acid cycle... [Pg.1317]

The citrate cycle is the final common pathway for the oxidation of acetyl-CoA derived from the metabolism of pyruvate, fatty acids, ketone bodies, and amino acids (Krebs, 1943 Greville, 1968). This is sometimes known as the Krebs or tricarboxylic acid cycle. Acetyl-CoA combines with oxaloacetate to form citrate which then undergoes a series of reactions involving the loss of two molecules of CO2 and four dehydrogenation steps. These reactions complete the cycle by regenerating oxaloacetate which can react with another molecule of acetyl-CoA (Figure 4). [Pg.117]

Robinson, J.B. Srere, P.A. (1985). Organization of Krebs tricarboxylic acid cycle enzymes in mitochondria. J. Biol. Chem. 260, 10800-10805. [Pg.153]

Senior, A.E. Shenatt, H.S.A. (1968). Biochemical effects of the hypoglycaemic compound pent-4-enoic acid and related non-hypoglycemic fatty acids. Oxidative phosphorylation and mitochondrial oxidation of pyruvate, 3-hydroxybutyrate and tricarboxylic acid-cycle intermediates. Biochem. J. 110,499-509. [Pg.153]

Purple sulfur bacteria fix carbon dioxide using the Calvin-Benson cycle, but green sulfur bacteria use a completely different pathway, the reverse tricarboxylic acid cycle. Other photosynthetic bacteria use still different pathways for CO2 fixation (Perry and Staley, 1997). [Pg.35]


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See also in sourсe #XX -- [ Pg.409 ]

See also in sourсe #XX -- [ Pg.28 , Pg.36 , Pg.52 , Pg.53 , Pg.54 , Pg.64 , Pg.65 , Pg.67 , Pg.163 , Pg.165 , Pg.169 , Pg.174 , Pg.177 , Pg.239 , Pg.248 , Pg.296 , Pg.311 ]




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