Tribenoside

Chemical Name Ethyl-3,5,6-tris-0-(phenylmethyl)-D-glucofuranoside 

Trade Name Manufacturer Country Year Introduced 

9 g of 3,5,6-tribenzyl-1,2-isopropylidene glucofuranose are kept overnight at room temperature with 100 cc of N-ethanolic hydrochloric acid. Evaporation under vacuum at below 50°C Is then carried out and the residue taken up in 150 cc of chloroform. The chloroform solu- 

The glucofuranose used as starting material is obtained as follows. 8.8 g of 1,2-isopropylidene-D-glucofuranose and 50.6 g of benzyl chloride are treated with a total of 28 g of potassium hydroxide in portions with cooling and stirring. The mixture is then stirred for 3 hours at 80 to 90°C. Working up from chloroform solution and distillation at 250°C to 260°C under 

and Huber, G.L. U.S. Patent 3,157,634 November 17, 1964 assigned to Ciba Corp. 

Trade Name Manufactu rer Country Year Introduced 

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Ethionamide Ethoheptazine Ethyl biscoumacetate Etiroxate Fenoxazoline Flurbiprofen Indobufen Indoramin Isocarboxazid Lofexidine Methotrexate Methyidopate Methylphenobarbital Nadoxolol Naphazoline Petindopril Phcnobarbital Propiverine Protionamide Proxazole Pyridoxine Retinol Thiamphenicol Tolazoline Tribenoside ethanolamine... 

A 57-year-old woman developed erythema exsudati-vum multiforme after using tribenoside 200 mg tds orally for 10 days (1). Patch tests with tribenoside (1% and 10% in petrolatum) showed erythema on days 2 and 3. Five controls were negative. 

Endo H, Kawada A, Yudate T, Aragane Y, Yamada H, Tezuka T. Drug eruption due to tribenoside. Contact Dermatitis 1999 41(4) 223. 

Tribenoside, ethyl-3,5,6-tri-O-benzyl-D-glucofuranoside, is used as an anti-hemorrhoidal in oral and suppository formulations. 

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