1,3,5-Triazine, 2,4,6-trichloro, coupling reactions

Coupling reactions of organoboronic acids with 2,4,6-trichloro-l,3,5-triazine have been investigated <04M1941>. 1,3,5-Trihydroxyisocyanuric acid (THICA) has been prepared by an efficient method from O-benzylhydroxyamine and diphenyl carbonate <04TL8277>. A novel class of multifunctional and multinucleate chalcogen (selenium and tellurium) containing derivatives 38 has been developed based on sequential chloride substitution of 2,4,6-trichloro-... 

Of the many other methods we can mention the preparation of biospecific adsorbents utilizing trichloro-5-triazine [120], coupling via thiol-disulfide interchange with activated thiolated support [121] or via azide formation [122]. The attachment of affinants containing the aromatic residues can be carried out by means of diazonium groups [87,123]. The coupling of the affinant onto the silinized glass after the reactions with p-nitrobenzoylchloride followed by reduction with sodium dithionite was described by Weetall and Filbert [124]. 

Additional Foolproof Synthetic Reactions Are Needed Professor Whitesides opened this subject by a challenge to the audience very few known synthetic reactions actually work I.e., work reliably in a foolproof fashion, in high yield, and in a way that is immune to variation in the structure of the substrates. One of the very few sequences for the coupling of molecules into larger entities that he has found to be fairly reliable is the formation of a chloroacetamide followed by a coupling with a thiolate. It is also possible to react trichloro-l,3,S-triazine with an amine quite reliably. Why are there so few other reactions that are really dependable ... 

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