Azide formation

Benzenediazonium fluoroborate, 2-carboxy-xanthone synthesis from, 3, 838 Benzenediazonium ions phenyl azide formation from, 5, 839 Benzenediazonium salts, o-(imidazol-l-yl)-intramolecular diazo coupling, 5, 404 Benzene-1,2-disulfonimides N-substituted reactions, 6, 930 Benzene episulfide formation, 7, 577 Benzeneimine... 

Qf-receptor blocking agent, 1, 176 Phenylalanine hydroxylase in tyrosine synthesis from phenylalanine, 1, 261 L-Phenylalanine hydroxylase mechanism, 1, 261 Phenyl azide formation... 

DUTT - WORMALL Azide formation Synthesis of aromatic azides from anilines via diazonium salts. 

Reactions of substituted cumyl benzoates in 50 50 trifluoroethanol-water show no effect of [NaN3] on the rate between 0 and 0.5 M. The product ratio, however, is highly dependent on the cumyl substituent. Electron-releasing substituents favor azide formation whereas electron-withdrawing substituents result in solvent capture. Formu-... 

In Reaction 12-9 treatment of Z—CH2—Z with tosyl azide gives diazo transfer. When this reaction is performed on a compound with a single Z group, formation of the azide becomes a competing process. " Factors favoring azide formation rather than diazo transfer include as the enolate counterion rather than Na orLi and... 

Reaction with sodium azide even at —78°C leads to explosions attributed to fluorine azide formation. 

The nonsymmetrical quinolizidine 373 was obtained from the acyclic symmetrical precursor 372 by means of a reaction sequence comprising azide formation, intramolecular 1,3-dipolar cycloaddition, thermal triazoline fragmentation to a diazoalkane, and Michael addition individual steps, as shown in Scheme 85 <2005CC4661>. 

However, the azide-based protocol often has problems with the formation of byproducts under both azide formation and subsequent reduction. 388 Therefore, mainly aminolysis is used. Glycosylamines are prepared from GlcNAc, GlcNAc2, Glc, maltotriose, mal-toheptaose, and di- and triantenneary complex glycans, isolated from asialofetuin by preparative hydrazinolysis. A modification of the method by Likhosherstov is also employed. 379 ... 

The mechanism of K azide formation with labeled N15 and its reactions are discussed by Clusius et al (Refs 44 47). 

R)-3-[(2S,35 )-2-Azido-3-(4-methoxy-2,6-dimethylphenyl)butanoyl]-4-phenyloxazoUdm-2-one (22A) Typical Procedure for Azide Formation (Scheme 10) [32)... 

Goodman and Chorev 75 found that the required a-aminoacyl azides 14 are best prepared by reaction of the mixed anhydride of the amino acid with sodium azide. This method led to slightly better yields than the nitrosylation of TV-formylaminoacyl hydrazide. Curtius rearrangement of the a-aminoacyl azide 14 yielded the isocyanate 16, which was subsequently trapped as 17 or 18 as shown in Scheme 2. Comparable yields were obtained by nitrosylation with tert-butyl nitrite. 76 Other methods of acyl azide formation have rarely been employed for PMRI-peptide synthesis. Only Fincham et al. 11 reported the use of trimethylsilyl azide to synthesize an acyl azide en route to a PMRI-peptide. 

A-(Benzyloxycarbonyl)-A -(ferf-butoxycarbonyl)niethanedianiine [18, R1=Boc R2=H R3=Bzl] by a Curtius Rearrangement with Azide Formation by a DPPA Reagent Typical Procedure 891... 

Alkali metal azides, 1 79 2 139 Alkali metal cyanates, 2 86 Alkali metal pyrosulfites, 2 162 Alkali metal sulfites, 2 162 Alkaline earth azides, 1 79 Allanite, extraction of, 2 44 Allophanyl azide, formation of, from allophanyl hydrazide, 5 51 Allophanyl hydrazide (1-amino-biuret), 5 48 hydrazones of, 5 51 from methyl and ethyl alloph-anates, 5 50 salts of, 5 51... 

Carbon tetrafluoride, 1 34 3 178 Carbon tetraiodide, 3 37 Carbonyl azide, formation of, by carbohydrazide, 4 35 Carbonyl fluoride, 6 155 Carbonyls, metal, 2 229 metal, nomenclature of, 2 264 structure of, 2 232 Catalysts, beryllium chloride, 5 25 boron fluoride, 1 23 chromium(III) oxide gel, 2 190... 

Azeotropic distillation, 20,66,106,23,38 Azide, formation from a hydrazine, 22,96 Azobenzene, 22, 28 Azoyl chloride, 25, 87 Azulene, removal from a hydrocarbon, 24, 86... 

Ortiz de Montellano PR, David SK, Ator MA et al (1988) Mechanism-based inactivation of horseradish peroxidase by sodium azide. Formation of meso-azidoprotoporphyrin IX. Biochemistry 27 5470-5476... 

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