Triamterene congestive heart failure

Triamterene can be used in the treatment of congestive heart failure, cirrhosis, and the edema caused by secondary hyperaldosteronism. It is frequently used in combination with other diuretics except spironolactone. Amiloride, but not triamterene, possesses antihypertensive effects that can add to those of the thiazides. 

Potassium-sparing diuretics include amiloride (Midamor) and triamterene (Dyrenium). They are used in the treatment of cirrhosis and congestive heart failure. They may be used in conjunction with thiazide diuretics to offset the potassium loss associated with those medications. 

Triamterene may be u.sed alone in the treatment of mild edema associated with congestive heart failure or cirrhosis of the liver with ascites, but it should not be given to patients with impaired renal function." It is not to be used alone in the treatment of hypertension. - Its primary use is in combination with hydrochlorothiazide (or other diuretics that act at site 2 or 3) to prevent the hypokalemia associated with the latter diuretics. 

Triamterene is usually recommended in the treatment of oedema associated with nephrotic syndrome, cirrhosis of liver, and congestive heart failure. It has also been used for the control and management of idiopathic oedema, steroid-induced oedema, oedema caused by hyperaldosteronism and in such oedematus patients who fail to respond to other therapy. It is usually used in conjunction with other diuretics like thiazides. 

Diuretics (Figure 4.8) are an important class of drugs which act on the kidney to increase urine output and thereby reduce the fluid load in the body. They are valuable in the treatment of hypertension and congestive heart failure. There are several modes of action possible which result in different effects on the amount of sodium and potassium ions excreted. The thiazide diuretics are exemplified by furosemide (Hoechst, 1964) which is among the world s top 25 products by sales value, and cyclopenthiazide (Ciba, 1961) which is currently among the top 20 products by prescription number in the UK. Because agents of this type lead to loss of potassium they are commonly prescribed with potassium chloride. Triamterene (Smith Kline and French, 1962) and amiloride (MSD, 1971) are diuretics which do not produce potassium loss. Amiloride and triamterene are commonly used as combinations with hydrochlorthiazide (Ciba, 1959). Spironolactone (Searle, 1962)... 

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