Trehalase inhibitors

POTENTIAL TREHALASE INHIBITORS SYNTHESES OF TREHAZOLIN AND ITS ANALOGUES... 

Several trehalase inhibitors have been isolated from natural sources these include deoxynojirimycin, validamycins, validoxylamines, salbastatin, calystigin B4, and trehazolin, the last one being the most potent. Trehazolin is used to control blight sheath of rice, caused by the plant pathogenic fungus Rhizoctonia solani, and it thus has potential fungicidal activity.12 15... 

S. Murao, T. Sakai, H. Gibo, T. Nakayama, and T. Shin, A novel trehalase inhibitor, trehalostatin, produced by Amycolatopsis trehalostatica HG-25, Agric. Biol. Chem., 55 (1991) 895-897. 

S. Ogawa, C. Uchida, and Y. Yuming, Synthesis of aminocyclitol moieties of trehalase inhibitors, trehalostatin and trehazolin, J. Chem. Soc. Chem. Commun. (1992) 886-888. 

C. Uchida, T. Yamagishi, and S. Ogawa, Total synthesis of the trehalase inhibitors trehalostatin and trehazolin, and of their diastereoisomers. Final structural confirmation of the inhibitor, J. Chem. Soc. Perkin Trans., 1 (1994) 589-602. 

S. Ogawa and C. Uchida, Total synthesis of trehalase inhibitor, trehazolin, Chem. Lett. (1993) 173-176. 

C. Uchida, T. Yamagishi, H. Kitahashi, Y. Iwaisaki, and S. Ogawa, Further chemical modification of trehalase inhibitor trehazolin Structure and inhibitory-activity relationship of the inhibitor, Bioorg. Med. Chem., 3 (1995) 1605-1624. 

Adenophorine-1 -0-P-D-glucopyranoside good trehalase inhibitor but moderate to poor inhibitor of other a-glucosidases ... 

S-Deoxyadenophorine good a- and p-galactosidase inhibitor and poor trehalase inhibitor ... 

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