Treatment with Renal Extracts Containing Hypertensinase

TREATMENT WITH RENAL EXTRACTS CONTAINING HYPERTENSINASE [Pg.538]

If hypertensin is the vasoconstrictor substance in hypertension, it should be possible to lower blood pressure by the administration of hyper-tensinase. Several investigators (96,129,130) reported favorable results [Pg.538]

Schales, Stead, and Warren (158) confirmed the blood-pressure-lowering effect of certain kidney extracts on hypertensive patients and found considerable hypertensinase activity in their preparations. The daily dose of extract (10 ml.) was obtained from 750 to 1000 g. of hog kidney. It contained an amount of hypertensinase capable of destroying at pH 7.4 in two hours as much hypertensin as is obtainable from 10 to 30 liters of beef serum, using an excess of renin under optimal conditions. These authors observed, [Pg.539]

The findings of Schales et al. (158) were confirmed by Remington, Cartland, Drill, and Swingle (148) and by Steveirs, Kotte, Smith, and McGuire (173). Remington et al. fractionated kidney extracts in order to isolate the material which lowered the blood pressure in hypertensive rats. No correlation could be observed between the blood-pressure-lowering activity and the hyportensinase contents of the various fractions. [Pg.540]

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