Traveling wave ion mobility

Scarff, C.A. Patel, V.J. Thalassinos, K. Scrivens, J.H., Probing hemoglobin stmcture by means of traveling-wave ion mobility mass spectrometry, J. Am. Soc. Mass Spectrom. 2009, 20, 625-631. 

Shvartsburg, A. A. Smith, R.D., Fundamentals of traveling wave ion mobility spectrometry, Anal. Chem. 2008, 80, 9689-9699. 

Morsa, D. Gabelica, V. De Pauw, E., Effective temperature of ions in traveling wave ion mobility spectrometry. Ana/. Chem. 2011, 83, 5775-5782. 

As described in previous chapters, there are many different types of ion mobility methods. These include drift tube ion mobility spectrometry (DTIMS), traveling wave ion mobility spectrometry (TW-IMS), differential mobility spectrometry (DMS), differential mobility analysis (DMA), and aspiration ion mobility spectrometry (alMS). All of these IMS methods have been interfaced to MSs. 

FIGURE 9.6 Schematic of a traveling wave ion mobility-mass spectrometer. (Available at http //pubs.acs.org/cen/coverstory/86/8637cover.html/. With permission.)... 

Knapman, T.W. Berryman, J.T. Campuzano, 1. Harris, S.A. Ashcroft, A.E., Considerations in experimental and theoretical collision cross-section measurements of small molecules using travelling wave ion mobility spectrometry-mass spectrometry, Int. J. Mass Spectmm. 2010, 298, 17-23. 

Q Applications of Traveling Wave Ion Mobility-Mass Spectrometry... 

TRAVELING WAVE ION MOBILITY-MASS SPECTROMETRY (TWIM-MS)... 

Slade, S.E. Thalassinos, K. Hilton, G.R. Pinheiro, T. Blindauer, C.A. Bowers, M.T. Scrivens, 1. Travelling wave ion mobility mass spectrometry-based conformational studies of prion protein - effects of metal cation binding and buffer gas. Proc. 56th ASMS Conference on Mass Spectrometry and Allied Topics, Denver, CO, lune 1-5, 2008, MP 457. 

Structural characterization of proteins and peptides using quadrupole ion trap mass spectrometry, Fourier transform-ion cyclotron resonance (FT-ICR) mass spectrometry, and traveling wave ion mobility mass spectrometry... 

Part 2. Ion Conformation and Structure presents discussions of structural characterization of proteins and peptides using quadrupole ion trap mass spectrometry, Fourier transform ion cyclotron resonance mass spectrometry, and the novel method known as traveling wave ion mobility mass spectrometry. In addition to the observation of collective fluctuations of the molecular substructures within biomolecules, the organization of atoms in small ion clusters is investigated using electron diffraction. 

Kaplan, K., Siems, W.F., and Hill, H.H. (2012) Resolving structural of monosaccharide methyl glycosides using drift tube and traveling wave ion mobility mass spectrometry. Anal. 

Ridenour, W.B., Kliman, M., McLean, J.A., and Caprioli, R.M. (2010) Structural characterization of phospholipids and peptides directly from tissue sections by MALDl traveling-wave ion mobility-mass spectrometry. Anal. Chem., 82, 1881-1889. 

For calculating relative collision cross sections using traveling wave ion mobility-MS, there are two main procedures used which can be found in the literature (29, 30). 

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