Traumatic brain injury therapeutic hypothermia

Palmer A. M., Marion D. W., BotschellerM. L., and Redd E. E. (1993) Therapeutic hypothermia is cytoprotective without attenuating the traumatic brain injury-induced elevations in interstitial concentrations of aspartate and glutamate. J. Neurotrauma 10, 363-372. 

Early reports of therapeutic hypothermia for severe traumatic brain injury can be traced back to the first half of the 20th century. It is only within the last two decades that clinical studies have demonstrated that therapeutic moderate hypothermia for brief durations can improve patient outcomes following brain injury. The historical background, recent clinical experience, and mechanisms of action of moderate hypothermia are reviewed. 

Several animal models suggest that the time to initiate cooling following TBI is brief. Some rat models suggest that the therapeutic window for treatment with hypothermia is approx 25 min (41,42). These data would seem quite discouraging, as most traumatic brain injury patients do not arrive at the hospital and receive complete evaluation until significantly more time has elapsed. Even with rapid transporta-... 

Therapeutic Moderate Hypothermia in Experimental Traumatic Brain Injury Models... 

Marion D. W. (1997) Therapeutic moderate hypothermia for severe traumatic brain injury. J. Intern. Care Med. 12, 239-248. 

McIntyre LA, Eergusson DA, Hebert PC, et al. Prolonged therapeutic hypothermia after traumatic brain injury in adults A systematic review. JAMA 2003 289 2992-2999. 

Bayir H, Andelson PD, Wisniewski SR, Shore P, Lai Y, Brown D, Janesko KL, Kagan VE, Kochanek PM (2009) Therapeutic hypothermia preserves antioxidant defenses after severe traumatic brain injury in infants and children. Crit Care Med 37 689-695... 

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