Trapping studies reactive metabolites

Utility of Reactive Metabolite Trapping and Covalent Binding Studies in Drug Discovery... 

ARE REACTIVE METABOLITE TRAPPING AND COVALENT BINDING STUDIES RELIABLE PREDICTORS OF TOXICITY POTENTIAL OF DRUG CANDIDATES ... 

Reactive metabolites [4] Elucidation of a potential metabolic prerequisite for toxicity of a chemical In vitro trapping studies available cellular systems developed only for radiolabelled substances Causality between reactive metabolite formation and toxicity difficult to prove... 

Liquid Chromatography-Mass Spectrometry (LC-MS)-Based Identification of Reactive Metabolites Via Trapping Studies... 

In the first case study, a lead candidate 12 (Fig. 6) was assessed for its potential to form reactive metabolites in LC-MS-based trapping assays using a variety of trapping agents. There were no indications of the formation of any thiol or cyanide adducts when GSH, N-acetylcysteine, or cyanide were included in incubations of 12 with human liver microsomes. However, when a tritium-labeled derivative of 12 was incubated with human liver microsomes under standard conditions... 

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