Tranylcypromine dosage

TRANYLCYPROMINE The usual effective dosage is 30 mg/day in divided doses. If there is no improvement after 2 weeks, increase dosage in 10 mg/day increments of 1 to 3 weeks. Dosage range may be extended to a maximum of 60 mg/day from the usual 30 mg/day. Withdrawal from tranylcypromine should be gradual. 

Four cases of addiction to tranylcypromine have been described, in addition to the three reported since 1965 (2). The dosage was 150-300 mg/day. The mild euphoriant properties of tranylcypromine reflect its structural resemblance to amfetamine, and probably account for tolerance and addiction in predisposed individuals. Tranylcypromine abuse in 18 patients has been reviewed (3), and two further reports have appeared (SEDA-17,17) (4). In one case (5), the patient took 440 mg/day without any adverse effects. The patient reported that she was longing for the energizing effect of the drug and for the feeling of freedom and power. Withdrawal resulted in repeated generalized seizures and status epilepticus. 

The dosage was 150-300 mg/day. The mild euphoriant properties of tranylcypromine reflect its structural resemblance to amfetamine, and probably account for tolerance and addiction in predisposed individuals. Tranylcypromine abuse in 18 patients has been reviewed... 

The most common adverse effect of MAOIs is postural hypotension this is more likely to occur with phenelzine than with tranylcypromine. Hypotensive reactions may be minimized through divided dosage scheduling. Anticholinergic side effects, especially dry mouth and constipation, are common but are milder in severity compared with those associated with the TCAs. 

Frequent Extrapyramidal effects anticholinergic effects Occasional Galactorrhea menstrual changes drowsiness postural hypotension anorexia rash tardive dyskinesia Rare Blood dyscrasias lenticular deposits and opacities (with long-term high dosage) ECG abnormalities convulsions neuroleptic malignant syndrome TRANYLCYPROMINE, see MAO inhibitors TRAZODONE... 

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